Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5593 | CA23180 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 74 |
| 2 | 3TC+AZT+SQV | 126 |
| 3 | D4T+NFV+NVP | 65 |
| 4 | D4T+DDI+IDV+RTV | 52 |
| 5 | 3TC+AZT+IDV+RTV | 37 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | K219Q | Y181C | K20R, T69N, R211A, F214L, L228R, K277R, R284K, T286A, I293V, P294PS, E297R, E302D |
| >CA23180| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLAWGLTTPDQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVVSLTREAE LD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73ST | L10I, K14R, M46X, K55R, I62V, L63P, A71V, I72X, P79PA, I93L |
| >CA23181| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKXIGGIGGFIRVRQYD QVPIEICGHKVXSTVLVGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |