Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5541 | CA23176 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+ DDI | 156 |
| 3 | AZT+ 3TC | 104 |
| 4 | 3TC+ DDI+ IDV | 25 |
| 5 | DDI+ RTV+ NFV | 17 |
| 6 | 3TC+ D4T+ NVP | 30 |
| 7 | DDI+ RTV+ SQV | 43 |
| 8 | None | 61 |
| 9 | APV+ RTV+ ABC+ NVP | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69T_N, K70R, L74V | D67G, K219Q | K103N, Y181C | K20R, V35I, K64N, S68Y, K122P, S134SN, F214L, D218E, D250E, K277R, R284K, T286A, I293V, E297A, I326V, Q334D, G335S, R356K, R358K, K366R, K390R, A400T, L452S, V458I, D460N, L469F, Q524E, K558R | P345PR |
| >CA23176| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAINKKGYTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPNINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGDSQWTYQIYQERFKNLKTGKYAKMKGA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKSGKAGYITNRGRQKVVSFTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEELIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRRVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A | L33LF | I15V, N37S, L63LP, A71V |
| >CA23177| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTIFEEMSLPGRWKPKIVGGIGGFMKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |