Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8033 | CA23175 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 34 |
| 2 | D4T | 43 |
| 3 | 3TC+ IDV+ D4T | 43 |
| 4 | None | 30 |
| 5 | 3TC+ RTV+ D4T+ SQV | 34 |
| 6 | D4T+ 3TC | 30 |
| 7 | D4T+ ABC+ RTV+ IDV | 13 |
| 8 | D4T+ 3TC+ IDV+ RTV | 80 |
| 9 | ABC+ DDI+ EFV+ LPV | 10 |
| 10 | Unknown | 16 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A, L90M | L10I, G16A, L19Q, N37S, R41K, K45R, L63P, I72V, Q92K, I93L |
| >CA23175| codons 1-99 PQITLWQRPIVTIKIAGQQKEALLDTGADDTILEEMSLPGKWKPRIVGGIGGFIKVRQYD QIPIEICGHKAVGTVLVGPTPANIIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | K122E, I135V, Q207E, V245K, K277R, I293V |
| >CA23174| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |