Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4374 | CA23172 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 83 |
| 2 | D4T+NFV+NVP | 30 |
| 3 | 3TC+AZT+SQV | 22 |
| 4 | None | 48 |
| 5 | D4T+EFV+IDV+RTV | 100 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215CY | K219E | K103N, Y181C | V108I | P4S, V60I, V90I, D123E, S162D, V179I, I195L, R211T, L228H, A272P, K281R, T286A, E297K |
| >CA23172| codons 1-300 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII CQYMDDLYVGSDLELGQHRTKIEELRQHLLTWGFCTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A, L90M | I13V, K43S, L63P, A71AV, I93L |
| >CA23173| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTILEEMNLPGRWSPKIVGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |