Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1251 | CA23168 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDC | 26 |
| 3 | AZT+DDI | 65 |
| 4 | 3TC+AZT+D4T | 39 |
| 5 | 3TC+D4T+DDI | 17 |
| 6 | 3TC+D4T+DDI+SQV | 13 |
| 7 | 3TC+RTV+SQV | 17 |
| 8 | 3TC+NVP | 26 |
| 9 | 3TC+AZT+IDV | 8 |
| 10 | 3TC+D4T+RTV+SQV | 9 |
| 11 | 3TC+D4T+NVP+RTV+SQV | 87 |
| 12 | 3TC+ABC+NVP+RTV+SQV | 30 |
| 13 | Unknown | 104 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219E | Y188L | V35I, V60VI, T69N, V118I, K122E, V179I, H208Y, K223E, L228H, V245R, A272P, K277R, I293V |
| >CA23168| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLLVGSDLEIGQHRTKIEELRQYLLRWGFFTPDEKHQEEPPFHWMGYELHPDKWT VQPIRLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I84V, L90M | L10F, L33I, N88D | I13V, E35D, M36I, R41K, L63P, I66V, A71V |
| >CA23169| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTIIEDINLPGKWKPKIVGGIGGFIKVRQYD QIPIEVCGHKVIGTVLVGPTPVNVIGRDLMTQIGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |