Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4518 | CA23167 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 265 |
| 2 | AZT+IDV | 57 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | DDI+DLV+NFV | 65 |
| 5 | ABC+APV+D4T+RTV | 107 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54L, V82T, L90M | V11I | L10Y, I15V, L19IT, K20I, M36I, N37D, R41K, K45R, L63P, A71V, I85V, Q92R |
| >CA23167| codons 1-99 PQITLWQRPYITIKVGGQIIEALLDTGADDTILEEIDLPGKWKPRMIGGIGGFLKVRQYD QIPIEICGHKVIGTVLVGPTPTNIVGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215FY | K219Q | Y181C | T7TA, K11KT, V35T, T39A, E44ED, V60VI, K101Q, K103R, K104KR, K122E, D123E, I135V, S162C, G196E, E203D, D218E, L228R, V245T, I293V |
| >CA23166| codons 1-301 PISPIEAVPVTLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKRRSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIDELRQHLWRWGFFTPEQKHQKEPPFRWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |