<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4518 CA23166 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 265
2 AZT+IDV 57
3 3TC+D4T+IDV 52
4 DDI+DLV+NFV 65
5 ABC+APV+D4T+RTV 107

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215FY K219Q Y181C   T7TA, K11KT, V35T, T39A, E44ED, V60VI, K101Q, K103R, K104KR, K122E, D123E, I135V, S162C, G196E, E203D, D218E, L228R, V245T, I293V  
>CA23166| codons 1-301
PISPIEAVPVTLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKRRSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKIDELRQHLWRWGFFTPEQKHQKEPPFRWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
L

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I54L, V82T, L90M V11I L10Y, I15V, L19IT, K20I, M36I, N37D, R41K, K45R, L63P, A71V, I85V, Q92R  
>CA23167| codons 1-99
PQITLWQRPYITIKVGGQIIEALLDTGADDTILEEIDLPGKWKPRMIGGIGGFLKVRQYD
QIPIEICGHKVIGTVLVGPTPTNIVGRNLMTRIGCTLNF

References
Author Title Citation
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005