Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4908 | CA23163 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 109 |
| 2 | AZT+DDI | 61 |
| 3 | AZT+DDI+SQV | 61 |
| 4 | 3TC+AZT+NVP | 17 |
| 5 | 3TC+AZT+NFV | 26 |
| 6 | EFV+RTV+SQV | 20 |
| 7 | ABC+D4T+DDI | 32 |
| 8 | ABC+EFV+RTV+SQV | 31 |
| 9 | ABC+D4T+LPV | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, V11I, Q58E, G73S | I15V, K20I, L63P, A71V, P79S, I85V | G16AV |
| >CA23163| codons 1-99 PQITLWQRPFITIKVAGQLIEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVREYD QIPIEICGHKVISTVLVGSTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V106A, G190A | V179D, F227L | V35I, K43Q, V118I, K122KN, D123E, K166R, D177E, G196E, R211K, T286A, I293V, E297K |
| >CA23162| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DNEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIDI YQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |