<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA9432 CA23156 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 157
2 D4T 109
3 D4T+DDI+SQV 21
4 AZT+NFV+NVP 78
5 ABC+IDV+RTV 130

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M G73T L10I, L19I, K20I, E35D, L63P, I64V, C67F, H69R, A71I, P79A, I93L  
>CA23156| codons 1-99
PQITLWQRPIVTIKIGGQIIEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFVKVRQYD
QIPVEIFGRKIITTVLVGATPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215Y V75I, K219E Y181C   V35R, K101Q, K122E, I135T, I142IV, T200A, L210F, L228H, I293V, E297A  
>CA23157| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRAKIEELRQHLFRWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009