Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9431 | CA23154 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | DDI+D4T+RTV+SQV+EFV | 52 |
| 3 | 3TC+AZT+EFV+IDV+LPV | 21 |
| 4 | D4T+DDI+RTV+SQV | 30 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76LV, I84V, L90M | F53FL | L10I, I13IV, K20R, E35D, M36I, N37E, K55R, R57K, D60E, L63P, I64V, A71V, I93L |
| >CA23154| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGIGGLIRVKQYE QIPVEICGHKVIGTVVVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, L210W, T215Y | V75I, F116Y | Y181C, G190S | K43N, K101Q, V111I, V118I, K122E, I142V, K173T, G196E, T200A, E203D, H208Y, R211K, V245K, A272P, K277R, T286A, E297K |
| >CA23155| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDIGDAYYSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSPAIFQSSMTKILEPFRTQNPDIVI CQYMDDLYVSSDLEIEQHRAKIDELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |