Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9428 | CA23149 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 187 |
| 2 | 3TC+D4T+RTV | 57 |
| 3 | 3TC+D4T+NFV+NVP | 43 |
| 4 | 3TC+AZT+LPV | 99 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181C | V108I | V35M, T39A, K43KQ, E44D, A98S, V118VI, I135IT, V179VI, H208Y, R211K, H221Y, A288T, I293V, E297R |
| >CA23149| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKTLTEVVPLTREA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, L33F, K43T, F53L, N83D | L10I, I13V, K20R, M36I, D60E, I62V, L63P, I64V |
| >CA23148| codons 1-99 PQITLWQRPIVTVKIGGQLREALIDTGADDTVFEEINLPGRWTPKMIGGIGGLVKVRQYE QVPVEICGHKAIGTVLVGPTPADIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |