<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TCDD-31 TCDD-31_1 Zimbabwe 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ 3TC+ SQV 43
2 APV+ NVP+ DDI 57

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, T215Y   Y181I   S3C, E6D, V35T, T39E, K122E, D123S, I142V, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D, A272P, K275R, Q278H, K281R, T286A, V292I, I293V, R307K  
>TCDD-31_1| codons 1-315
PICPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMLKILEPFRTKNPEIVI
IQYMDDLYVGSDLEIGQHRAKIDELREYLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCRLLRGAKALTEIVPLTEEAE
LELAENKEILKEPVH

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54FL L33F L10I, T12S, I15V, L19I, E34D, M36I, R41K, D60E, L63P, H69K, T74E, P79PL, I85V, L89M, I93L Q58QP
>TCDD-31_1| codons 1-99
PQITLWQRPIVSIKVGGQIKEALLDTGADDTVFDEINLPGKWKPKMIGGIGGFFKVRPYE
QIPIEICGKKAIGEVLVGLTPVNIVGRNMLTQLGCTLNF

References
Author Title Citation
Kantor, R HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy. ARHR, 2002
Johnston, E High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. J Virol, 2003