<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TCDD-33 TCDD-33 Zimbabwe 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 DDI 8
2 IDV+ D4T+ DDI 104
3 3TC+ AZT+ IDV 31

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15IV, L19I, K20R, M36I, R41K, H69K, L89M, I93L  
>TCDD-33| codons 3-99
ITLWQRPLVSIKVGGQIREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQI
LIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39E, S48ST, V60I, K122E, D123GS, G141X, I142X, R143X, K166R, K173A, Q174R, D177E, I178IM, T200A, Q207E, R211K  
>TCDD-33| codons 28-241
EEKIKALTEICEEMEKEGKITKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDF
WEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPXXXYQYN
VLPQGWKGSPAIFQSSMTRILEPFRARNPEMVIYQYMDDLYVGSDLEIGQHRAKIEELRE
HLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTV

References
Author Title Citation
Kantor, R HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy. ARHR, 2002
Johnston, E High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. J Virol, 2003
Kassaye, S Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. JAIDS, 2009