Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TCDD-30 | TCDD-30_1 | Zimbabwe | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ NFV+ 3TC | 4 |
| 2 | 3TC+ AZT+ IDV | 10 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, T39E, S48T, E53D, K122E, D123GS, K173T, D177DE, I178IL, I195K, T200A, Q207A, R211K |
| >TCDD-30_1| codons 26-243 LTEEKIKALTEICEEMEKEGKITKIGPDNPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQ DFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGIRYQ YNVLPQGWKGSPAIFQSSMTKILEPFRTQNPELVIYQYVDDLYVGSDLEKGQHRAKIEEL RAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, T12A, I15V, L19I, E35D, M36I, N37ND, R41K, H69KQ, L89M, I93IL |
| >TCDD-30_1| codons 2-99 QITLWQRPIVAIKVGGQIKEALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVRQYDQ ILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |
| Kantor, R | HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy. | ARHR, 2002 |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |