Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
TCDD-25 | TCDD-25 | Zimbabwe | 2001 | HIV1 | C | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | NVP+ IDV | 21 |
2 | D4T+ NVP+ IDV | 10 |
3 | EFV+ SQV+ RTV | 18 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
T12S, I15V, L19I, M36I, L63LP, H69K, L89LM, I93L |
>TCDD-25| codons 3-99 ITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYDQI PIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
V35T, E36A, T39E, S48T, K64KR, K122E, K173A, Q174K, D177E, T200TA, Q207A, R211RK |
>TCDD-25| codons 29-242 EKIKALTAICEEMEKEGKITKIGPENPYNTPVFAIRKKDSTKWRKLVDFRELNKRTQDFW EVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNV LPQGWKGSPAIFQSSMTKILEPFRAKNPEIVIYQYMDDLYVGSDLEIGQHRAKIEELRAH LLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQ |
References
Author | Title | Citation |
Kantor, R | HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy. | ARHR, 2002 |
Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |
Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |