Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TCDD-22 | TCDD-22 | Zimbabwe | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 52 |
| 2 | DDI+ 3TC+ AZT | 9 |
| 3 | SQV+ NVP+ IDV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, M36I, R41K, L63A, H69K, I93L |
| >TCDD-22| codons 5-99 LWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQIAI EICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K103N | K32E, V35T, E36A, T39K, K43E, S48T, K122E, D123S, K173A, T200A, Q207E |
| >TCDD-22| codons 29-244 EKIEALTAICKELEEEGKITKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFW EVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETPGIRYQYNV LPQGWKGSPAIFQSSMTKILEPFRAQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELREH LLRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPI |
References
| Author | Title | Citation |
| Kantor, R | HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy. | ARHR, 2002 |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |