<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    A38N, S39C, L45Q, I72V, T125V, I182V, V201I, D207N, K211T  
>consensus_0364| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVNCCDKCQQKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTVVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FVHNFKRKGGIGGYSAGERIIDIIATNIQTTELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    K14R, G17E, K45R, K55R, R57K, I62V, L63P, A71T  
>consensus_0364| codons 1-99
PQITLWQRPLVTIRIGEQLKEALLDTGADDTVLEEMNLPGRWKPRMIGGIGGFIRVKQYD
QVPIEICGHKTIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    Y181C   V35T, T39L, K122E, D123E, I135T, T200A, Q207E, L228H, T286A, T296S, E297K, R307K, D324E, K366R, A376T, E399D, A400T, V435E, K454R, D460N, R461K, S468T, L491S, L503I, K512Q  
>consensus_0364| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICLEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLSKEAE
LELAENKEILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVRQLTEAVQKITTESIVIWGKTPKFKLPIQKETWDTWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIEGAETFYVDGAANRETKLGRAGYVTNKGRQKVVTLTDTTNQKTELQ
AIHLALQDSGSEVNIVTDSQYAIGIIQAQPDQSESELVSQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Rolland, M Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial Nat Med, 2011