<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    I84V, L101I, T112A, T125A, M154I, V165I, Q177L, F181Y, L234I  
>consensus_1399| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYVEAEVIPAETGQETAYFILKLAGRWPVKAIHTDNGSN
FTSTAVKAACWWAGIKQEFGIPYNPQSQGVVESINKELKKIIGQIRDQAEHLKTAVLMAV
YIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    N37T, L63S, I64L, I72V, V77I, I93L  
>consensus_1399| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFIKVRQYD
QISLEICGHKAVGTVLIGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E28A, Q207GR, R211K, V245M, A272P, T286P, E297A, V317A, I329L, T338S, E344D, M357T, V365I, T369V, A376T, K390R, T397M, A400S, T403A, K431T, L452LI, D460N, R461K, H483Y, L491S, E516D, S519N, A534T, I556V, K558R  
>consensus_1399| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRRHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVIPLTAEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQGQGQWSYQIYQDPFKNLKTGKYARTRGA
HTNDIKQLVEAVQKITTESIVIWGKTPKFRLPIQKEMWESWWAEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIVGAETFYVDGAANRETKIGKAGYVTNKGRQKVVSLTDTTNQKTELQ
AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESDLVNQIIEQLIKKEKVYLTWVPAHK
GIGGNEQVDKLVSAGVRRVL

References
Author Title Citation
Rolland, M Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial Nat Med, 2011