Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF-10 | JF10-M8 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | D4T+3TC+NFV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I15V, M36I, R41K, L63P, H69Q |
| >JF10-M8| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADNTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGQKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K22N, K43N, K122E, D123E, A158S, R211K |
| >JF10-M8| codons 14-249 PGMDGPKVNQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPVFAIKKKDSTKWRK LVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIP SINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDL EIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEK |
References
| Author | Title | Citation |
| Fitzgibbon, JE | Emergence of drug resistance mutations in a group of HIV-infected children taking nelfinavir-containing regimens. | ARHR, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |