Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF-8 | JF8-M10 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ DDI | NA |
| 3 | AZT+ 3TC | NA |
| 4 | D4T+ DDI+ NFV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | V35M, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228H | Y56S |
| >JF8-M10| codons 22-260 KQWPLTEEKIKALMEICTELEKEGKISKIGPENPSNTPVFAIKKKNSNRWRKLVDFRELN KRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPG IRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTI IEELRQYLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I | N88D | T12E, K14R, Q61E, L63P, V77I |
| >JF8-M10| codons 1-99 PQITLWQRPLVEIRIGGQLKEALLDTGADNTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD EIPIEICGHKAIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Fitzgibbon, JE | Emergence of drug resistance mutations in a group of HIV-infected children taking nelfinavir-containing regimens. | ARHR, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |