Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JF-1 | JF1-M4 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+ 3TC | NA |
| 3 | D4T+ DDI+ NVP | NA |
| 4 | DDC+ NVP+ NFV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | M36I, N37S, R57K, L63P |
| >JF1-M4| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEISLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K103N, Y181C | K22N, V35T, T39A, R83K, A98S, K122E, I178L, R211K, V245E |
| >JF1-M4| codons 14-249 PGMDGPKVNQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRK VVDFRELNKKTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIP SINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVICQYMDDLYVGSDL EIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIELPEK |
References
| Author | Title | Citation |
| Fitzgibbon, JE | Emergence of drug resistance mutations in a group of HIV-infected children taking nelfinavir-containing regimens. | ARHR, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |