Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | SQV+ RTI | 9 |
| 2 | IDV+ RTI | 81 |
| 3 | SQV+ RTV+ RTI | 32 |
| 4 | IDV+ NFV+ RTI | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46VL, I54V, V82A, N88NS | L24I, F53FL | L10I, T12D, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, A71V |
| >DK-6905| codons 1-99 PQITLWQRPIVDIRVGGQLREALIDTGADDTVLEDINLPGKWKPKVIGGIGGLVKVRQYD QIPIEICGKRVIGTVLVGPTPANIIGRSLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219E | V35T, T39K, K43Q, V60I, V118I, D121H, K122E, I135V, K173T, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245Q, E248D, D250E, A272P, K275R, Q278N, T286A, A288V, V292I, E297A |
| >DK-6905| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEQEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLFTPDEKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLLRGAKVLTEIIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Kempf, DJ | Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. | J Virol, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Mo, H | Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates. | J Virol, 2005 |