Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+NRTI | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S | E35D, N37D, K45KR, L63P, I64V, I72V |
| >DK-6273| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPRMIGGIGGFIKVRQYD QIPVEICGHKAVGTVLVGPTPVNIIGRSLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219H | I5V, E6D, K20R, E44D, V60I, V118I, D123E, D177E, G196E, T200I, E203D, Q207E, H208Y, R211K, L228H, T286A, I293V, E297K, I329V, G333E, Q334Y, M357T, E399D |
| >DK-6273| codons 1-400 PISPVDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRIKIDELREYLWKWGFYTPDHKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEYGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Kempf, DJ | Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. | J Virol, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |