Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CR0050Z | CR0050Z | U.S. | 2006 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, K14R, S24N, I72V, P90S, S119P, T122I, T125A, V126M, V201I, T206S, D256E |
| >CR0050Z| codons 1-288 FLDGIDKAQEDHERYHSNWRAMANDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVISAETGQETAYFLLKLAGRWPVKTIHTDNGPN FISTAMKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q58E | E35D, R41K, D60E, Q61E, L63P, I93L |
| >CR0050Z| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMNLPGKWKPKMIGGIGGFIKVREYE EIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| S162C, E169D, D177E, G196E, R211H, E248N, T286A, I293V, P294T, K311R, Q334L, T338S, M357T, R358K, T369A, E370N, K390R, L469I, T470P, H483Y, K512Q, L517V, S519N, K527T |
| >CR0050Z| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLHWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPNKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVTLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGLGQWSYQIYQEPFKNLKTGKYARTKGA HTNDVKQLANAVQKIATESIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSIPDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESEVVNQIIEQLITKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Wang, YE | Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. | J Virol, 2009 |