<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    L28I, P30A, S39C, L101I, S119T, K188R, V201I, T206S, Y227F, L234V, A265V  
>CR0027M| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNIPAVVAKEIVACCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGTN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRRGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYFRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V   L10V, I13V, E35D, M36I, L63P, A71V, I72V  
>CR0027M| codons 1-99
PQITLWQRPVVTVKIGGQLKEALLDTGADDTVLEDINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHKVVGTVLVGPTPANVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, Q151M T215V, K219Q K103N   V35I, K102R, V118I, K122E, D123G, I135T, K173N, Q174K, R211K, F214L, A272P, A288S, V292I, E297K, D324E, G333E, Q334N, G335S, T338S, K366R, A371V, A400T, V435I, D460S, R461K, L491S, A554S  
>CR0027M| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSIPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRNKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLVTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQENSQWSYQIYQEPFKNLKTGKYARMRGA
HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTSKGRQKVVSLTDTTNQKTELQ
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Wang, YE Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. J Virol, 2009