<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S24G, D25E, S39C, L45Q, S119P, T122I, T125A, T206S, N254NK S283N
>BEC57| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMAGEFNLPPVVAKEIVACCDKCQQKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGPN
FISTAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDKSDIKVVPRRKAKIIRDYGKQMAGDDCVANRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, N37AV, R57K, Q61H, I62V, I64V, C67Y, I72V, V77VI  
>BEC57| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDMVLPGRWKPKMIGGIGGFIKVKQYD
HVLVEIYGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
      V108I V35I, K122Q, I135M, E138A, V179I, D192E, R211K, A272P, T286A, E297A, R307RK, Q334E, M357R, T369A, S379G, T386I, K390R, A400T, E404D, V435I, L452A, D460N, T470A, L517IV, S519N  
>BEC57| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL
DQDFRKYTAFTIPSMNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYMDDLYVGSELEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAE
LELAENKEILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARRRGA
HTNDVKQLAEAVQKIATEGIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKAGKAGYVTNRGRQKVVSLADTTNQKTELQ
AIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESEVVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Miura, T Genetic characterization of human immunodeficiency virus type 1 in elite controllers: Lack of gross genetic defects or common amino acid changes. J Virol, 2008