<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D6E, E11D, E13D, A21T, V31I, S39N, I72V, Q95A, E96D, T112V, T124N, T125A, G134N, I135V, K136R, D167E, H171Q, V201I, L234I S283G
>AA110b01L| codons 1-288
FLDGIEKAQEDHDKYHSNWRTMASDFNLPPIVAKEIVANCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGADTAYFLLKLAGRWPVKVIHTDNGSN
FTSNAVKAACWWANVRQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEQLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, M36I, R41K, H69K, L89M  
>AA110b01L| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6N, K11T, V35T, T39K, K43E, K49R, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, I244V, V245Q, T286A, E291D, V292I, I293V, P294Q, E297A, K311R, E312T, I326V, G335D, M357K, G359S, K366R, A371V, A376V, T386A, K390R, A400T, T403M, E432D, N447S, R448K, L452Q, K454R, R461K, D471E, Q480H, H483Y, K512R, L517V, S519N, Q524E, K530R, V531I, A554S  
>AA110b01L| codons 1-560
PISPINTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPVQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVQLTAEAE
LELAENREILRTPVHGVYYDPSKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVRQLTEVVQKIVTESIVIWGKAPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAASKETKQGRAGYVTDKGRQKVVSLTETTNQKTELH
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDRSESEVVNQIIEELIKKERIYLAWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012