<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  V151I E11D, A21T, V31I, I72V, T112V, T124A, T125A, G134N, I135V, D167E, V201I, L234I S283G, R284G
>AA092b06L| codons 1-288
FLDGIDKAQEDHEKYHSNWRTMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANVKQEFGIPYNPQSQGVIESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGGQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, G16E, E35D, M36I, R41K, H69K, K70R, L89M  
>AA092b06L| codons 1-99
PQITLWQRPIVTVKIEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V35M, T39K, K43E, K122E, D123S, I142V, S162C, K173R, Q174K, D177E, T200I, E203D, Q207A, R211S, K238R, V245E, E248D, K249Q, K281R, T286A, E291D, I293V, E312T, I326V, I329V, G333E, M357N, G359S, K366R, A371V, V381I, K390R, K395R, A400T, T403M, E432D, E449D, D471E, Q480H, H483Q, L491P, L517V, Q524E, K530R, A534S, A554S K512MR
>AA092b06L| codons 1-560
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRRKNPEIVI
YQYMDDLYVGSDLEIGQHRIKIDELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDRWT
VQPIELPDQDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVPLTEEAE
LELAENREILKTPVHGVYYDPSKDLVAEVQKQEQGQWTYQIYQEPFKNLKTGKYARNRSA
HTNDVRQLTEVVQKIATESIIIWGKTPKFRLPIQRETWETWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRDTKLGKAGYVTDRGRQKVVSLTETTNQKTELH
AIQLALQDSGPEVNIVTDSQYALGIIQAQPDRSESEVVSQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012