<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L33F I13V, E35D, M36I, P39S, R41K, R57K, H69K, L89M  
>AA081a_01L| codons 1-98
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVFEDINLSGKWKPKMIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLN

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V35T, T39K, K43E, S162C, K173I, Q174K, D177E, Q207A, R211S, K238R, V245E, K249R, V276I, K281KR, T286A, E291D, I293V, E312T, I326V, I329V, G335D, T338S, Y342F, K350R, M357K, G359S, K366R, A371V, K390R, K395R, E399D, A400T, T403M, E432D, N447S, D471E, Q480H, I482V, L491S, A502V, K512R, E514D, L517I, S519N, Q524E, A534S, A554S  
>AA081a_01L| codons 1-560
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRIKNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDRWT
VQPIELPERDSWTVNDIQKLVGKLNWASQIYAGIKIKQLCRLLRGAKALTDVVPLTEEAE
LELAENREILKTPVHGVYYDPSKDLVAEVQKQGQDQWSYQIFQEPFKNLRTGKYARKRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQRETWDTWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAASRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH
AVHLALQDSGSEVNIVTDSQYVLGIIQAQPDRSDSEIVNQIIEELIKKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, A21T, A23V, D25E, S39N, M50I, I72V, L101V, T112V, T124A, T125A, G134N, I135V, K136R, I141T, D167E, V201I, K215R, L234I S283G
>AA081a_01L| codons 1-288
FLDGIDKAQEEHERYHSNWRTMVSEFNLPPVVAKEIVANCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFVLKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANVRQEFGTPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQRQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012