<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, A21T, V32I, S39N, I72V, L101I, T112V, T125A, G134N, I135V, K136R, D167E, V201I, L234V E152K, S283G
>AA077a_LH33| codons 1-288
FLDGIDKAQEEHERYHSNWRTMASDFNLPPVIAKEIVANCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWANVRQEFGIPYNPQSQGVVKSMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I   I13V, E34K, E35N, M36I, R41K, H69K, L89M  
>AA077a_LH33| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLKNINLPGKWKPKIIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, K20R, V35T, E36A, T39K, K43E, K122E, D123N, I135T, S162C, K173A, Q174K, D177E, I178M, T200I, Q207A, R211S, F214L, V245E, V276I, T286A, E291D, V292I, E312T, S322A, I326V, I329V, G335D, M357K, G359S, K366R, A371V, K390R, A400T, E432D, L452Q, D460N, D471E, K476Q, Q480H, L491S, L517V, S519N, Q524E, A534S, A554T G18E, G262E
>AA077a_LH33| codons 1-560
PISPIDTVPVKLKPGMDEPRVKQWPLTEEKIKALTAICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEMVI
YQYMDDLYVGSDLEIGQHRIKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVEKLNWASQIYAGIKIKQLCKLLRGAKALTDIIPLTEEAE
LELAENREILKTPVHGVYYDPAKDLVAEVQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKQGKAGYVTNRGRQKVVSLTETTNQQTELH
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEVVNQIIEELIKKEKVYLSWVPAHK
GIGGNEQVDKLVSTGIRKVL

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012