<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, S17N, L28I, S39N, L45V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, G163E, D167E, V201I, K211R, L234I S283G
>AA024a08| codons 1-288
FLDGIDKAQEEHERYHNNWRAMASDFNIPPVVAKEIVANCDKCQVKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANVRQEFGIPYNPQSQGVVESMNKELKKIIEQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, M36I, R41K, H69K, L89M  
>AA024a08| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
      V179D E6D, K20R, V35I, T39K, K122E, D123S, I135T, K173I, Q174K, D177E, Q207A, R211S, F214L, V245E, A272G, T286A, I293V, E312T, I329V, G335D, M357K, G359S, V365I, K366R, A371V, I375M, T386I, K390R, A400T, T403M, E432D, V435I, N447S, D471E, Q480H, G490E, L491S, K512R, E514D, L517V, S519N, Q524E, A534S, A554S  
>AA024a08| codons 1-560
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALIEICKEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIDI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKTPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDIRQLTEVVQKMATESIVIWGKIPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIIGAETFYVDGAASRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH
AIHLALQDSESEVNIVTDSQYALGIIQAQPDRSDSEVVNQIIEELIKKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012