<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  L74M K14R, V31I, S39N, D41N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, I141V, K160Q, D167E, R187K, V201I, L234I, V249I, D279A S283G, R284G, D286N
>AA002a_LH13| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVANCNKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVIMVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANVQQEFGVPYNPQSQGVVESMNKELKQIIGQVREQAEHLKTAVQMAV
FIHNFKKKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAIVIQDNSDIKVVPRRKAKIIRDYGKQMAGDACVAGGQNED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, M36I, R41K, R57K, L63P, H69K, L89M  
>AA002a_LH13| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39K, K43E, K122E, D123S, I135L, S162C, R172K, K173I, Q174K, D177E, I178M, Q207A, R211S, V245E, T286A, E291D, V292I, I293V, P294Q, E312T, D324E, I326V, I329V, G335D, M357R, G359S, K366R, A371V, A400T, E432D, D460N, D471E, Q480H, H483Y, G490E, L491S, K512R, L517I, S519N, Q524E, A534S, A554S H221HR
>AA002a_LH13| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKIKNPEMVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLSWGFTTPDKKRQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVQLTEEAE
LELAENREILKTPVHGVYYDPSKELVAEVQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTETTNQKTELH
AIYLALQDSESEVNIVTDSQYALGIIQAQPDRSESEIVNQIIEELIKKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012