<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, L19M, E35D, M36I, R41K, I62V, L63P, H69K, V77I, V82I, L89M  
>AA001a12L| codons 1-99
PQITLWQRPLVTVKIGGQMKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGKKAIGTVLIGPTPINIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174K, D177E, T200A, Q207A, R211S, V245E, K249R, T286A, E291D, V292I, I293V, P294S, E312T, I329V, Q334N, G335D, E344D, M357K, G359S, K366R, A371V, A376V, T386A, K395R, A400T, E432D, N447S, D460N, D471E, Q480H, H483Y, L491S, K512R, L517V, S519N, Q524E, A534S, A554S  
>AA001a12L| codons 1-560
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPERDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVSLTEEAE
LELAENREILKTPVHGVYYDPSKDLIAEVQKQGNDQWTYQIYQDPFKNLKTGKYARKRSA
HTNDVRQLTEVVQKIVTESIVIWGKAPKFKLPIQRETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAASRETKLGKAGYVTNRGRQKVVSLTETTNQKTELH
AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESEVVNQIIEELIKKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K7Q, E11D, A21T, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I S283G
>AA001a12L| codons 1-288
FLDGIDQAQEDHEKYHSNWRTMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANVRQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Rolland, M Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 Nature, 2012