<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JS25 JS98291 Luxembourg 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDC+RTV 96
2 3TC+D4T+IDV 72

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, V75M, M184V, L210W, T215Y       D123E, D177E, I178V, V179I, T200I, L228R, V245K, W252G  
>JS98291| codons 25-252
PLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKRT
QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRY
QYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVIIYQYVDDLYVGSDLEIGQHRIKIEE
LRQHLWRWGFYTPDKKHQKEPPFRWMGYELHPDKWTVQPIKLPEKDSG

References
Author Title Citation
Servais, J Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol, 2001
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005