<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JS14 JS99285 Luxembourg 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDC NA
2 3TC+AZT+SQV 24
3 AZT+DDI+SQV 24
4 AZT+DDI+RTV 36
5 DLV+D4T 12
6 NVP+D4T+IDV 72

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, Q58E L10I, I15V, K20R, E35D, M36I, N37D, R41K, K55N, L63Q, H69Y, I85V, L89M G51K
>JS99285| codons 4-99
TLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGKWKPKLIGGIKGFVNVREYDQIQ
IEICGYKAIGTVLVGPTPANIVGRNMLTQIGCTLNF

References
Author Title Citation
Servais, J Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol, 2001
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005