<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JS6 JS98371 Luxembourg 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI+ AZT+ RTV NA
2 DDC+ AZT+ RTV 120
3 3TC+ IDV+ D4T 12

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, L210W, T215Y K219N     V111I, I135T, S163C, D177E, I178M, E194G, G196E, T200I, H208Y, R211K, V245T  
>JS98371| codons 25-252
PLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRT
QDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRY
QYNVLPQGWKGSPAIFQSCMTKILEPFRKQNPEMVIYQYVDDLYVGSDLGIEQHRIKIEE
LRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWTVQPITLPEKDSW

References
Author Title Citation
Servais, J Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol, 2001
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005