<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JS3 JS98471 Luxembourg 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI NA
2 3TC+AZT+IDV 24
3 3TC+D4T+IDV 12
4 3TC+AZT+IDV 24
5 NVP+3TC+D4T 48

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, T215Y   K103N   A98S, D123E, I135L, I178M, R211K, D250T  
>JS98471| codons 25-252
PLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRT
QDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSLNNETPGIRY
QYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIGQHRTKIEE
LRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKTSW

References
Author Title Citation
Servais, J Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol, 2001
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005