<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5981 CA21453 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 56
2 3TC+AZT 109
3 3TC+AZT+RTV 74
4 DDI+DLV+NFV 17
5 D4T+DLV+RTV+SQV 65
6 ABC+APV+DDI 52
7 ABC+APV+D4T+RTV 51

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54IM, I84V, L90M L33F L10I, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71V, P79AS  
>CA21453| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDISLPGKWKPKLIGGIGGFMKVRQYD
QVPIEICGHKVIGTVLVGATPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LV, L210W, T215Y K219N K103N, Y181C, G190A   K20R, T39A, E40X, K43E, E44EA, V118VI, K122P, R172RK, Q174R, E203K, Q207E, H208Y, R211K, K223T, L228H  
>CA21236| codons 1-260
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAXLEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKRNPDIVI
CQYMDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDNKHQTEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKL

References
Author Title Citation
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005