Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5286 | CA21389 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 69 |
| 2 | AZT+DDI | 39 |
| 3 | AZT+3TC | 30 |
| 4 | AZT+IDV+3TC | 26 |
| 5 | D4T+IDV+3TC | 206 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54V, V82A | L89LV | L10LI, I15V, K20R, M36I, K55R, R57K, L63P, I66IF, A71I, I85V |
| >CA21389| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTILEEINLPGRWKPKLIGGIGGFVRVKQYD QIPIEFCGHKIIGTVLVGPTPANIVGRNVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | E44ED, S68SG, V118VI, K122E, I135T, Q207E, E291D, E297K, D324E, R356K, A360T, K366R, A376S, K390R, K395R, E399D, A400T, V435A, D460N, T470S, L491S, S519N, K527T, E529D, K530R |
| >CA21172| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVRQLTEAVQKISTESIVIWGKTPKFRLPIQRETWDTWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLSDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLITKDRVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |