Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4305 | CA21351 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 218 |
| 2 | 3TC+AZT | 22 |
| 3 | 3TC+AZT+RTV | 61 |
| 4 | 3TC+AZT+NVP | 48 |
| 5 | D4T+DDC+NFV | 48 |
| 6 | 3TC+D4T+EFV+IDV | 85 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | N88D | I15V, E35D, M36I, N37D, L63P, I64IV, A71AV, V75I |
| >CA21351| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKVIGTILVGPTPANIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SG, M184IV | A62V | Y181C, G190A | K101HQ | E6K, K64R, K103KR, K122E, I135V, Y144F, E204D, H221Y, I293V, E297K |
| >CA21130| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIRKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRFQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYIDDLYVASDLEIGQHRTKIEDLRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |