<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 38

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N P225H V35K, E36A, T39E, S48T, V60I, I135M, S162C, T165L, K173A, Q174K, D177E, G196E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, G335D, R356K, M357K, R358K, G359S, A360AT, E370D, T377M, K390R, E399D, A400T, T403S, E404D, E432D, A437AV, R461K, H483K, L491A, K512N, S519N, K530R, A534S, A554S  
>58ZA.39| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMLKILEPFRAKNPEIVI
YQYVDDLYVGSDLEIEQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKKST
HTNDVKQLTDAVQKIAMESIVIWGKTPKFRLPIQKETWDTWWSDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGVETFYVDGAANRETKLGKAGYVTDKGRQKVVSLTDTTNQKTELQ
AIKLALQDSGAEVNIVTDSQYALGIIQAQPDNSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012