<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 72

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V A62AV V106M, G190A   V35T, T39E, S48T, K122E, I135R, I142V, K173T, Q174K, D177E, G196E, T200A, Q207E, V245E, L283I, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357S, G359S, T377R, V381I, K385R, K390R, A400T, E404D, E432D, V435A, A437V, F440Y, L452LI, R461K, V466I, V467I, S468T, T470N, D471E, T477A, H483Q, L491S, S519N, K527Q, K530R, V531I, A534S, A554K Y232H
>54ZA.72| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL
DEDFRKYTAFTIPSRNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
YQYVDDLYVASDLEIEQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGHELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKSRSA
HTNDVKQLTEAVQKIARESIIIWGRTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIAGVETYYVDGAANRETKIGKAGYVTDKGRQKIITLNETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKERIYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012