<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 108

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N, Y188YH V108VI, P225PH L34LI, V35T, T39D, K122P, I135IT, K173T, Q174K, D177E, T200A, Q207E, R211K, H221HY, V245Q, E248D, D250E, A272P, K277R, E291D, V292I, I309IV, V317A, Q334H, G335D, R356K, M357V, R358K, G359A, K366R, T369A, A376AT, T377M, T386TA, K390R, A400T, E404D, E432D, V435I, L452I, V458I, V466I, T470N, D471E, T477A, H483Q, G490E, L491A, L517I, S519N, K527N, K530R, A534S, A554T  
>51ZA.108| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKAITEICDEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
YQYVDDLHVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKYQKEHPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIIPLTEEAE
LELAENREVLKEPVHGAYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKVKAA
HTNDVRQLAEAVQKITMESIVIWGKAPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIIGAETFYVDGAANRETKIGKAGYITDRGRQKIVSLNETTNQKAELQ
AIQLALQDSEAEVNIVTDSQYALGIIQAQPDKSESEIVNQIIEQLINKERVYLSWVPAHK
GIGGNEQVDKLVSTGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012