<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 48

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103KN, V106VM, G190S   V35T, T39K, S48T, V60I, K122E, D123S, I135T, T165I, K173A, Q174K, T200E, E203EK, Q207A, R211K, F214L, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357MR, G359S, T386V, K390R, A400T, E404D, V435A, E449ED, V466VI, D471E, Q480H, L491S, L517LI, S519SN, Q520K, K527EGQR, K530R, A534S, A554NS H483H*QY
>48ZA.36| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAKNPDIVI
YQYVDDLYVSSDLEIGQHREKIKELRAHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSA
HTNDVKQLTEAVQKIATESIVIWGKVPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRDTKLGKAGYVTDRGRQKIVSLTETTNQKTELH
AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEIVNKIIEQLIRKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012