<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 89

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V N348NI K101KE, Y181C A98G V35T, T39K, S48T, V60I, K122E, D123S, I135IT, K173A, D177E, T200A, Q207A, R211K, D218DE, V245Q, D250E, A272P, K277R, T286A, K287KQ, E291D, V292I, I293IV, E297A, Q334E, G335D, R356K, M357R, G359T, A376C, T377MR, K390R, A400T, E404D, I434M, V435A, A437V, L452IV, V467I, S468T, T470N, D471E, H483Q, L491S, L517I, S519N, Q524E, K530KR, A534S, A554S  
>43ZA.84| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
CQYVDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPEKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAQALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEDQWTYQIYQEPFKILKTGKYAKRRTA
HTNDVKQLTEAVQKICRESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGVETFYVDGAANRETKVGKAGYVTDRGRQKVITLNETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEIVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012