<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 23

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V N348NI V106VM, Y188C   V35T, T39K, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207A, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, E297A, Q334E, G335D, R356K, M357R, G359T, A376C, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452IV, V467I, S468T, T470TN, D471E, H483Q, L491S, L517I, S519N, Q524E, K530KR, A534S, A554S  
>43ZA.24| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
YQYVDDLCVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEDQWTYQIYQEPFKILKTGKYAKRRTA
HTNDVKQLTEAVQKICMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGVETFYVDGAANRETKVGKAGYVTDRGRQKVITLNETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEIVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012