<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 90

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   Y181C   V35T, E36A, T39E, E40D, S48T, K49R, K122E, D123S, K173A, Q174K, D177E, T200A, Q207N, V241L, V245Q, A272P, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, N348NT, R356K, G359T, T377LS, K390R, A400T, E404D, V435A, A437V, N447S, E449D, L452V, V467I, S468T, L469I, T470S, D471E, H483Q, L491S, Q509L, S519N, K530R, A534S, A554S  
>39ZA.84| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKITRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI
CQYVDDLYVGSDLEIGQHRAKIEELRNHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
LQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKTLKTGKYAKMRTA
HTNDVKQLTEAVQKIASESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGVETFYVDGAASRDTKVGKAGYVTDRGRQKVITISETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQALPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012