<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 48

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    V106M   E28A, V35T, E36EA, T39E, S48T, K122E, D123G, I135T, S162C, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, K238R, V245Q, D250E, A272AP, K277R, T286A, E291D, V292I, I293V, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, E432D, L452K, V466I, S468P, D471E, T477A, H483L, G490E, L491V, E492K, S519N, K527N, K530R, V531I, L533M, A534S, A554N, K558R  
>25ZA.48| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGLTTPDKKHQKEPPFLWMGYELHPDRWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKKGKAGYVTDRGRQKIVPLTETTNQKAELQ
AILLALQDSEVKVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYMSWVPAHK
GIGGNEQVDKLVSNGIRRVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012