<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 96

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V N348I K103N   V35T, E36A, T39D, S48T, K122E, D123G, I135T, E138A, S162A, K173T, T200A, Q207D, R211K, D250E, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, P294S, Q334H, G335D, R356K, G359T, K366R, T369A, T377L, K390R, E399G, A400T, E404D, N447I, L452I, V467I, T470S, D471E, T477A, H483Q, L491S, L517X, S519N, K527N, K530R, V531I, A534S, A554S  
>24ZA.48| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIQVKHLCKLLRGAKALTDIVSLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKILKTGKYAKMRTA
HTNDVRQLAEAVQKIALESIVIWGKTPKFRLPIQKETWGTWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAAIRETKIGKAGYVTDRGRQKVISLSETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEXVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012