<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
20ZA 20ZA.108 South Africa 2007 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 135

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N   K20R, V35T, E36A, T39E, S48T, K122E, D123G, I135L, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, T286A, E291D, I293V, E297K, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, F416Y, L452I, V466I, V467I, D471E, H483K, L491S, S519N, K527R, E529D, K530R, A534S, A554N  
>20ZA.108| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEYVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKIGKAGYVTDRGRQKIISLTETTNQKTELQ
AIKLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIRKDRVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012