Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 20ZA | 20ZA.108 | South Africa | 2007 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+EFV | 135 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | K20R, V35T, E36A, T39E, S48T, K122E, D123G, I135L, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, T286A, E291D, I293V, E297K, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, F416Y, L452I, V466I, V467I, D471E, H483K, L491S, S519N, K527R, E529D, K530R, A534S, A554N |
| >20ZA.108| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEYVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKIGKAGYVTDRGRQKIISLTETTNQKTELQ AIKLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIRKDRVYLSWVPAHK GIGGNEQVDKLVSNGIRKVL |
References
| Author | Title | Citation |
| Brehm, JH | Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. | Clin Infect Dis, 2012 |